Deletion mutants of VPg reveal new cytopathology determinants in a picornavirus.
BACKGROUND: Success of a viral infection requires that each infected cell delivers a sufficient number of infectious particles to allow new rounds of infection.In picornaviruses, viral replication is initiated by the viral polymerase and a viral-coded protein, termed VPg, that primes RNA synthesis.Foot-and-mouth disease virus (FMDV) is exceptional